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KMID : 0388019950060030131
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Korean Journal Gynecologic Oncology and Colposcopy
1995 Volume.6 No. 3 p.131 ~ p.139
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Clinical Effects of Recombinant Human G-CSF (Neutrogin) on Neutropenia Induced by the Cancer Chemotherapy for Gynecologic Malignancy.
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이효표
고창원/오성일/박창수/송용상/강순범
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Abstract
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This study in undertaken to investigate the clinical effects of Neutrogin(recombinant) human granulocyte-colony stimulating factor) in 25 patients with ovarian cancer who received two courses of CAP chemotherapy.
In the first course of chemotherapy as a control course, all patients were treated with CAP chemotherapy alone and during the second course, Neutrogin was given at a dose of 2㎍/㎏/day subcutaneously for 14 days 24 hours after completion of
chemotherapy. Neutrogin significantly increased the nadir count of leukocyte and absolute neutrophil and decreased the number of days per patient on which the absolute neutrophil count was 1,000/㎣ or less. The mean recovery time required for
neutrophil
to greater than 1,500/㎣ after nadir were significantly decreased in the second courese a compared with the first course. Each one patient experienced mild side effects on Neutrogin, such as fever, bone pain and malasie and recovered without
treatment.
These results showed that Neutrogin is extremely effective and useful to treat chemotherapy induced leukopenia and to accelerate the recovery from these complications.
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KEYWORD
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